In Figures 1, 2 and 3, a thin slice from a montaged tomographic reconstruction of a region of a crypt of Lieberkühn in HIV-1 infected humanized Bone Marrow Liver Thymic (BLT) mouse colon is shown. In Figures 1 and 2, the virions themselves have been modeled in position (the envelopes as blue spheres, the bullet-shaped cores in magenta and presumptive surface spikes as tiny yellow spheres) and the tomographic slice superimposed beneath them. This view allows for the virions in the intercellular spaces between cells to be visualized relative to the surrounding tissue components.
The images shown were provided by Mark S. Ladinsky and Pamela J. Bjorkman, PhD, of the California Institute of Technology, Pasadena, CA and Douglas Kwon, MD PhD, of the Ragon Institute of MGH, MIT and Harvard and Harvard University, Cambridge, MA.